International Journal of Advanced Science and Research

International Journal of Advanced Science and Research


ISSN: 2455-4227

Vol. 2, Issue 6 (2017)

Syringic acid, a polyphenol modulates detoxification agents on 7,12-dimethylbenz[a]-anthracene induced oral carcinogenesis in golden Syrian hamsters

Author(s): Periyannan Velu, Veerasamy Vinothkumar, Sukumar Babukumar, Duraisamy Ramachandhiran
Abstract: The status of detoxification agents were used as biochemical end points to assess the chemo preventive potential of syringic acid (SA), a polyphenol, in 7,12-dimethylbenz[a]- anthracene (DMBA)-induced hamster buccal pouch carcinogenesis. Topical application of 0.5% DMBA in liquid paraffin, thrice a week for 10 weeks on their buccal pouches hasmters. 100% tumor formation was noticed in hamsters treated with DMBA alone, orally administration of SA, at a dose of 50 mg/kg bw., to DMBA-treated hamster completely prevented the development of oral tumors. Moreover, SA significantly restored the status of phase I and phase II detoxification agents and favoring the secretion of carcinogenic metabolite, during DMBA-induced oral carcinogenesis. The present study concludes that the chemo preventive potential of SA relies on its modulatory effects on phase I and II detoxification agents to excrete the carcinogenic metabolite, during DMBA-induced hamster OSCC.
Pages: 90-95  |  572 Views  170 Downloads
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