Vol. 2, Issue 6 (2017)
Bacteriological profile and antibiotic resistance pattern in blood stream infection in critical care units of a tertiary care hospital in central India
Author(s): Dr. Krishna Kumar Patel, Dr. Sarita Patel, Dr. Deepak Sinha
Abstract: Blood stream infections (BSIs) are an important cause of morbidity and mortality worldwide. The condition can be life threatening in critically ill patients in intensive care units (ICUs) of the hospitals. The case fatality rate associated with BSIs in ICU patients is between 35% - 50%. Risk factors contributing to these infections are many but leading causes are intravascular catheters (IVCs), debilitating condition of the patients due to some underlying infection or invasive diagnostic or therapeutic procedures. Blood stream infections (BSIs) are an important cause of morbidity and mortality worldwide. The condition can be life threating in critically ill patients in intensive care unit (ICUs) of the hospital. Emergence of resistance among the bacterial pathogens causing these infections is another issue of the public health concern. This study was carried out in our to medical college in Bilaspur India, to know the spectrum of bacterial pathogens causing BSIs in the patients admitted to the critical care units also to know the trends of resistance among these agents. It was a hospital based retrospective cross-sectional study and was carried out in tertiary care hospital in Central India. The data was collected by reviewing the records of 565 patients admitted to various critical care units (ICUs) of the hospital from May 2016 to March 2017. Out of total 565 blood samples of the patients suspected of bacteremia, admitted to critical care units of the hospital 140 were culture positive. Out of these isolates 74(53%) were Gram positive bacteria (GPB) and 55(39.3%) were Gram negative bacteria (GNB) and 11(7.9%) were non-albicans Candida. The predominant bacterial isolate were Coagulase negative staphylococcus (CoNS) 49 (34.5%) followed by Enterobacter cloacae 22 (15.4%) and Staphylococcus aureus 20 (14%). The antimicrobial resistance profile of both Gram positive and Gram negative isolates showed a high prevalence of resistance among them. This study will provide the clinicians an update on high prevalence of multi-drug resistant isolates in the critical care units of the hospital.