International Journal of Advanced Science and Research

International Journal of Advanced Science and Research


International Journal of Advanced Science and Research
International Journal of Advanced Science and Research
Vol. 4, Issue 4 (2019)

Molecular docking studies of delonix elata heat shock protein (HSP70) ATPASE: An enzyme target for brain attack


Mariappan Senthilkumar M, Sami Veerappa N, Lokesh Thangamani, Gowdham Manivel, Praveen Kumar, Shanmughavel P, Murugesh Easwaran

Heat Shock Protein (HSP 70) Atpase enzyme is neurological disorder enzyme present human brain cells. Quercetin (QU), Rutin (RU) and Hesperitin (HE) was taken as ligand for molecular docking with brain targets. Heat Shock Protein (HSP 70) Atpase whose crystallographic structures are available on the PDB database 2E1Q was used for the docking analysis using the Schrödinger Suite tool. The docking studies of the enzyme Heat Shock Protein (HSP 70) Atpase with two ligand quercetin, rutin and hesperitin reveals that these lead molecules can be used in drug development for brain attack. Phytochemical screening of alkaloid, steroid, triterpenoid, flavonoid, protein, amino acid, tannins, phenolics, glycosides, saponins, carbohydrates, volatile oils, fatty acids, emodins of phytoconstituents have been carried out.
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How to cite this article:
Mariappan Senthilkumar M, Sami Veerappa N, Lokesh Thangamani, Gowdham Manivel, Praveen Kumar, Shanmughavel P, Murugesh Easwaran. Molecular docking studies of delonix elata heat shock protein (HSP70) ATPASE: An enzyme target for brain attack. International Journal of Advanced Science and Research, Volume 4, Issue 4, 2019, Pages 56-63
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