International Journal of Advanced Science and Research

International Journal of Advanced Science and Research


International Journal of Advanced Science and Research
International Journal of Advanced Science and Research
Vol. 5, Issue 2 (2020)

Effect of intravenous magnesium sulphate infusion during spinalanasesthesia on postoperative pain following caesarean section


Mahmoud Ahmad Abd El Salam, Mohamed Adel Abdou

Caesarean section is the most widely performed obstetric procedure, Post-operative pain is one of the greatest concerns after caesarean delivery. Currently, opioids are commonly used for relief of post-operative pain but the usage of opioids is associated with many undesirable side effect Thereafter, there are needs for alternative analgesic drugs to reduce the amount and side effects of opioids such as magnesium sulphate. Objective: This study aims to evaluate the effect of intravenous infusion of magnesium sulphate during spinal anesthesia on post-operative analgesia and post-operative analgesic requirements in patients undergoing elective caesarean section. Methods: Total number involved in this study are sixty adult patients scheduled for elective cesarean section under spinal anaethesia, their ages ranged from 21 to 40 years. Spinal anesthesia was performed at L3-4 or L4-5 interspace. After Dural puncture with a 25 G Quincke needle, hyperbaric bupivacaine 0.5% solution 12.5 mg with fentanyl 25 microgram (µg) was injected Group (A): 30 Patients received magnesium sulphate 50 mg/kg for 20 min after spinal anesthesia and then 8 mg/kg/h by continuous IV infusion by syringe pump until end or surgery. Group (B): 30 Patients received the same volume of isotonic saline over the same period. Results: The time for first need of analgesia was significantly shorter in group II than group I in patients who require ketolac supplements. Total dose of analgesic consumption in the 24-hour postoperative period was significantly higher in group II than in group I. (P=0.010) There was no statistically significant difference between the two studied groups regarding perioperative side effects as nausea, vomiting, hypotension, bradycardia and shivering. Conclusion 1. The addition of intravenous magnesium sulphate during spinal anaesthesia significantly improves pain scores and provides prolonged postoperative analgesia in caesarean section procedures. 2. The addition of intravenous magnesium sulphate during spinal anaesthesia provides stable hemodynamics without significant side effects. 3. The addition of intravenous magnesium sulphate during spinal anaesthesia provides no significant effects on the APGAR score.
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How to cite this article:
Mahmoud Ahmad Abd El Salam, Mohamed Adel Abdou. Effect of intravenous magnesium sulphate infusion during spinalanasesthesia on postoperative pain following caesarean section. International Journal of Advanced Science and Research, Volume 5, Issue 2, 2020, Pages 14-17
International Journal of Advanced Science and Research