The World Health Organization (WHO) has estimated that Diabetes will be one of the world leading causes of death and disability with next quarter century. The global epidemic of type II Diabetes, predominantly affects the people of the retirement age. Half of all people with Diabetes older than 65 years are hospitalized each year, and severe and life threatening complications often contribute to the increased rate of hospitalization. Purpose of this study was to evaluate the effectiveness of Foot Reflexology on glycemic levels among Diabetics with Oral Hypoglycemic agents and Insulin. Sixty Diabetics were selected through the simple random sampling technique and their Post Prandial Blood Sugar (PPBS) was checked as pre test. Experimental group and Control group composed of 30 samples (15 on Oral Hypoglycemic agent and 15 on Insulin) respectively. 3 members each, from both the Experimental groups (I and II), received Foot Reflexology daily for 3 weeks, and no treatment was given to the Control group. All the participants were reassessed after 3 weeks to assess the effectiveness of the intervention. Findings revealed that mean pre test glycemic level of Experimental group I (166.13) was higher as compared with post test score (117.93) and the mean pre test glycemic level of Experimental group II (153.73) was higher as compared with post test score (109.80). Also, there was a significant difference between the Experimental group II and Control group II (p = 0.005), Thus, the study revealed that Foot Reflexology was found to be very effective in reducing the serum glycemic levels among the Diabetics.