The problem of appearance of toxic materials in water ecosystem is closely connected with increased concentration of different types of pollutants, which enter water bodies with industrial and communal waste waters. The extensive use of cadmium in industry and the degree of its toxicity indeed pose an environmental problem. The objective of the present work is to study the haematological changes in the fresh water fish Labeo rohita treated with sub lethal doses of cadmium chloride and to estimate the accumulation of the metal in the vital organs like gill, liver and kidney. The LC50 at 96 hrs was determined by the Probit analysis method. The experiment was designed to expose the fish to sub lethal concentrations of cadmium chloride - 500µg/l, 700µg/l, and 900µg/l. The haematological profile of the control and treated fish included Haemoglobin, total RBC and WBC count, platelet count and the erythrocyte indices of fish, MCV and PCV. The heavy metal cadmium was analysed by Atomic Absorption Spectroscopy. A significant decrease in the RBC, WBC, Platelet count, Haemoglobin, MCV and PCV was observed in different concentrations. A significant increase in cadmium chloride was observed in the gill, liver and kidney of the fish. Haematological and biochemical profile in fish is proved to be a sensitive index for the evaluation of fish metabolism under metallic stress.