Mosquitoes are one of the most medically significant vectors and they transmit parasites and pathogens, which continue to have devastating impact on human beings. Culex quinquefasciatus is an important vector of Brancraftian filariasis in tropical and subtropical regions. The current study on Larvicidal assay of Duranta repens linn. and Vitex negundo linn. Against culex quinquefasciatus say. Focuses on preparing mosquito repellents against Culex quinquefasciatus say. By soaking the dried leaf powders in equal proportion of the two species in different solvents, their efficacy in using against mosquito have been analysed. Among the three solvents used, distilled water and methanol showed higher mortality percentage.