Background: Atherosclerosis is a multifactorial disease with various risk factors playing significant role in its pathogenesis. There are various known but underestimated risk factors like uric acid and albumin which are reported to have the potential as risk predictors of atherosclerosis.

Aims and Objectives: To estimate the level of serum uric acid and albumin and study their association with angiographically proven atherosclerosis.

Material and Methods: Study population consisted of angiographically proven 50 cases with atherosclerosis and 50 controls without atherosclerosis. All routine parameters were analysed on SYNCHRON CX-9 using standard kits.

Results: Mean serum uric acid levels of cases were significantly higher than the controls with p=0.007; mean serum albumin levels of controls were significantly higher than the cases p=0.009. No statistically significant difference was found in lipid profiles of two groups.

Conclusion: Increased uric acid and decreased albumin are associated with atherosclerosis risk. But their potential as an independent risk predictor remains inconclusive as their role in atherosclerosis whether it is direct or indirect via promotion of other risk factors is not clear.