CoQ10 is of nutritional nature and is an intracellular antioxidant which is widely distributed in the tissues of the human body. A deficiency of CoQ10 at gingival sites may exist independently of and /or because of periodontal disease. Aims: The present study was designed with the aim to evaluate the antigingivitis effect of coenzyme Q10 on plaque induced gingivitis Methods and material: A total 40 systemically healthy gingivitis subjects aged 16-64 years, were divided into 2 groups randomly, control group (A):-20 subjects with gingivitis were treated with scaling, test group (B):-20 subjects with gingivitis were treated with scaling and topical application of Perio Q gel for a period of 28 days.Statistical analysis. Repeated two way analysis of variance (ANOVA) followed by post hoc tukey test for intergroup comparisons. Results. There was statistically significant reduction in plaque index scores, gingival scores and sulcular bleeding scores in the control group but in the test group showed a gradual reduction in sulcular bleeding index. There was a clinical improvement in both the tests and controls Conclusion Topical application of PerioQ gel along with mechanical debridement has improved clinical parameters. Further long term clinical trials in larger sample sizes with long term revaluation are needed for their use in routine supportive periodontal therapy.