B.Sc (N) First Year Students are found to be at risk of stress because they have to adjust in hostel life along with cultural differences, academic pressures, clinical demands etc. A RCT study using parallel group design was conducted to determine the effectiveness of PMR (Progressive Muscle Relaxation) as stress reducing intervention among 50 B.Sc (N) Students studying in First Year at selected nursing college ( Indore). The main objective of the study is to compare PMR techniques with Physical Activity in reducing stress among study and control group.50 eligible participants were enrolled using allocation concealment and randomly divided into study and control group and they received respective intervention i.e. PMR and Physical Activity of choice. 33 participants were analysed. It was single blinded trial and CONSORT flow diagram was used. After intervention 64% of the study group participants were in the category of low stress in comparison to only 32% in control group The effect size is D=1.89(larger effect), So this indicates that PMR technique in comparison to Physical Activity has larger effect in reducing stress. On the basis of results it could be concluded that PMR is an effective technique to reduce the stress of B.Sc (N) First Year Students.