Chronic obstructive pulmonary disease (COPD) is a chronic lung problem that needs higher attention. Smoking and pollution are main causative agents of this health problem. Inflammation and Oxidative stress are the major markers of COPD and antioxidant enzyme status can be used as biomarker to assess various chronic diseases. Antioxidant defense system plays an important to control oxidative stress caused by free radicals and other reactive species (reactive oxygen species and reactive nitrogen species). In COPD subjects, permanent oxidative stress continuously produced in the body caused imbalanced response of endogenous antioxidant enzyme. So, this disease is major public health problem and life threatening. This is the time to generate some treatment and drugs to prevent and cure the chronic lung disease.