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VOL. 2, ISSUE 4 (2017)
A potential effect of Curcuma aromatica Salisbury rhizome against Ehrlich ascites carcinoma in Swiss albino mice
Authors
Madan L Kaushik, Surya P Gautam, Bharti Dhaharwal
Abstract
The aim of this study was to investigate the potential antitumor effect of the petroleum ether and ethanol extracts of Curcuma aromatic rhizome (Zingiberaceae) in Swiss albino mice against Ehrlich Ascites Carcinoma (EAC) cell line. The EAC cells were injected (i.p.) into twenty four mice (divided into 6 numerically equal groups), and after a one-day incubation period, the extracts were administered to the mice daily for 14 days. The antitumor activity of the petroleum ether and ethanol extracts of Curcuma aromatica at doses of 200 mg/kg body weight was evaluated against Ehrlich ascites carcinoma (EAC) tumor in mice. The antitumor activity was assessed using mean survival time (MST), tumor volume, tumor cell count, and haematological profile.
Results indicate that the oral administration of the petroleum ether and ethanol extracts of Curcuma aromatic increased the mean survival time, tumor volume, tumor weight, body weight and tumor cell count were also significantly reduced. haematological parameters including protein and PCV, which were altered by tumor inoculation, were restored. The effects of both extracts were comparable with standard drug cyclophaspamide.
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Pages:109-112
How to cite this article:
Madan L Kaushik, Surya P Gautam, Bharti Dhaharwal "A potential effect of <em>Curcuma aromatica</em> Salisbury rhizome against Ehrlich ascites carcinoma in Swiss albino mice". International Journal of Advanced Science and Research, Vol 2, Issue 4, 2017, Pages 109-112
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