In the present study, Schiff base was prepared using 2-Aminopyridine with 3, 5-dichlorosalicylaldehyde and after that tellurium (IV) complexes were synthesized using the Schiff base. The structures of the newly synthesized complexes and Schiff base were analyzed by elemental analyses, conductivity measurements, FT-IR and proton NMR spectral studies. The tellurium(IV) complexes are distorted octahedrally coordinated by phenolic oxygen as well as azomethine and pyridine nitrogen atoms to give rise the formula of complexes is [TeCl₃(2-APY-{3,5-ClSal})], [RTeCl₂(2-APY-{3,5-ClSal})] and [R₂TeCl(2-APY-{3,5-ClSal})]: where R = 4-methoxyphenyl, 4-hydroxyphenyl, 3-methyl-4-hydroxyphenyl. Also, the Schiff base and some of their tellurium (IV) complexes were tested in vitro to evaluate antifungal and antibacterial activities.