The relationship between lipid profile, BMI and CD4+ count is not well understood among HIV infected male and female individuals. The purpose of this study was to understand the lipid profile parameters along with the BMI and CD4+ cell count of HIV infected participants and also to find the impact of sexual dimorphism in it. The present cross-sectional study assessed the lipid profile, BMI and CD4+ status of 100 HIV-infected and 100 HIV-non-infected individuals from the Jangalmahal areas and adjacent areas of three districts of West Bengal attending the Midnapore Medical College and Hospital. The changes in serum TC, TG, HDL, VLDL were insignificant when compared between HIV+ and HIV- cases. Significantly higher levels of LDL among female positive participants were observed. A negative correlation between BMI and LDL was established among infected females. LDL level was increased proportional to the increase in CD4+ cells particularly for female individuals. The changes in lipid-profile may be a good marker of disease progression in HIV infected females.