The present paper deals the extracts from leaf, seed coat and stem of Cardiospermum halicacabum L. in different solvent, were subjected to phytochemical and antibacterial screening against the selected Gram positive and Gram negative bacteria. All the extracts showed varying degree of inhibitory potential against all the tested bacteria. (Acetone, Chloroform and Diethyl ether) extracts of seed coat had higher inhibitory action against Pseudomonas, Escherichia coli, Staphylococcus aureus and Salmonella respectively. Chloroform extract of stem, leaf and seed coat had moderate inhibitory action against Escherichia coli and Staphylococcus.