An evaluative one group pretest and post test approach was used to conduct a study to assess impact of Nurses’ led Intervention on the psychosocial factors affecting nutritional status to change the behaviour in prevention of anaemia among adolescent girls, Sample size of 200 adolescent girls studying in government schools of Indore city were selected using non probability purposive sampling technique. Dependent variable was nutritional anaemia, psychosocial factors and independent variables were nurses’ led interventions. the significance value for change in all measurements are less than 0.05(P=0.000), we can conclude that the average difference of 21.61 per girl of dietary scores and 10.33 in rating scores are not due to chance variation, and can be attributed to after 15 days program. i.e. statistically significant difference between before and after program in both nutritional status and level of knowledge among adolescent girls of 12-18 years of age.