High risk of cardiovascular diseases in postmenopausal women is due to the abrupt interruption of estrogen which has direct protective effects on lipids, glucose metabolism and on vessel function. Timely prevention of cardiovascular diseases in postmenopausal women can reduce the burden to their family in terms of medical expenses, long term treatment, and job related problems etc. A quantitative pre-experimental experimental study was conducted to evaluate the effectiveness of Nurse Led Intervention on knowledge regarding post-menopausal lifestyle to prevent cardiovascular diseases, 40 menopausal women were selected as sample by using non probability purposive sampling technique. Data was collected through structured knowledge questionnaire before and after administration of Nurse led Intervention in form of structured teaching programme. Results showed that mean post-interventional knowledge score (21.2) is apparently higher than the mean pre-interventional knowledge score (13). The mean difference between pre-interventional knowledge score and post-interventional knowledge score is 4.2. The computed ‘t’ value 8.7 (2.25, P<0.05 df: 39) shows that there is a significant difference between pre-interventional knowledge score and post-interventional knowledge score.