Coleus rotundifolius L. is highly medicinal plant of family Lamiaceae. It is used in various traditional diseases. In the present study a chemical test performed against the, all the phytochemical constituents for their preliminary screening of each solvent extract of leaf like water, methanol, chloroform, ethyl acetate, and acetone. From the phytochemical investigation of the leaf extracts; the result is revealed the presence of carbohydrates, glycosides, tannins, flavonoids, triterpenoids, and lipids in all the solvent extracts. But phenols are more retain in methanolic leaf extract remain all the phytochemical constituents.