During present investigation Carissa carandas has phytochemically analysed. The plant metabolites like and found in forests of Sidhi district of (M.P.). The fresh leaf and fruit of Carissa carandas were extracted using non polar solvent i.e. chloroform, followed by ethanol, dichloromethane, acetone, toluene, ethyl acetate. The extract was then tested for his or her antimicrobial activities by agar well diffusion technique. The methylene chloride and resolvent extract of leave showed higher results against the Styphylococcus aureus sp. and enterobacteria respiratory disease than the opposite solvent. The fruit extract of C. carandas in methylene chloride were showed the utmost bactericide activity against the E. coli among the opposite take a look at small organisms. A fruit extract in ester showed the higher result against the all strains. it's terminal that C. carandas fruit extract have antimicrobial activity, thus we will use it as seasoning medication.